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Biopharmaceuticals Proteins Peptides Oligonucleotides

Large biomolecules are usually ionisable

By John Comer
- 03 February | 2016

Titrating proteins, peptides and oligonucleotidesLarge biomolecules are usually ionisable, and some have lots of pKas. Acid-base titrations of proteins were often done in the 50s and 60s, and Charles Tanford published a great review in 1962 [1]. It’s... Read more