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Download your copy of our 2016 AAPS posters

By Rebecca Heys

You can now download the posters we presented at AAPS November 2016. Covering a wide range of topics including work on IVIVC with our Biphasic Dissolution methods, the study of subcutaneous formulations and work with cocrystals, these posters represent the wide-ranging research we have been involved in over the last year both in our own labs in the UK and with our global collaborators.

Cyclodextrins: Determination of the stability constant of Warfarin, Dipyridamole and Piroxicam and the impact on solubility in the presence of Cavasol and Captisol

This study shows the determination of stability constants and the impact on the solubility of three medicinal compounds, Warfarin, Dipyridamole and Piroxicam in the presence of the cyclodextrin derivatives Cavasol and Captisol. 

Study of the impact of different salts on the intrinsic dissolution rate of pharmaceutical compounds

We investigated the effect on the intrinsic dissolution rate (IDR) and the mass released of a free base and four complimentary salts over the course of 2 hour experiments in an aqueous system. This research aimed to understand the effect of the counterions and identify the best salt that reached the highest concentration in solution by the end of the experiment.

Controlled supersaturation in Simulated Gastrointestinal Media (SGIM): Experiments and model

To develop and validate a novel, low volume experiment for the assessment of API supersaturation, nucleation and precipitation in simulated gastrointestinal media (SGIM). Using Classic Nucleation Theory (CNT) and a new mechanistic approach, the data could be modelled allowing for prediction of the nucleation and precipitation at different supersaturation levels.

In vitro study of Lidocaine and Enoxaparin subcutaneous formulations performance using Sirius Scissor

Lidocaine and Enoxaparin are among the most important medications needed in a basic health system and are part of the WHO Model List of Essential Medicines. Both can be administered subcutaneously and the work here described relates to their release rate, and physical behaviour upon injection using Sirius Scissor. 
The data collected during this study could be compared with previously described in vivo data and allow for the establishment of in-vivo in-vitro correlation

Dissolution rate of some poorly soluble drugs and their novel cocrystals

The aim of this study is to compare the dissolution rate at different pH values of poorly soluble drugs with that of the prepared cocrystals, and to investigate the possible changes in the solid state of drugs and their cocrystals during the dissolution process. 

Hydrochlorothiazide cocrystals: Structure, solubility and biphasic dissolution studies

To better understand the solubility and dissolution properties of a BCS class IV drug Hydrochlorothiazide (HCT). Being a class IV drug it has low solubility and permeability and hence exhibits poor oral absorption. This study attempts to improve the physicochemical properties of the drug (solubility and biphasic dissolution) using a crystal engineering approach.

Biphasic dissolution studies of poorly water-soluble drugs

An automated biphasic dissolution assay was used to study the lipid absorption of poorly water soluble drugs and covering a range of acidic, basic and neutral compounds. The pH of the aqueous phase was adjusted to pH 6.5 to represent intestinal pH and decanol was selected as the lipid layer. The passage of drug into the lipid phase simulates the absorption into the gut wall. The protocols used take advantage of robotics and automation to ensure well-designed, reproducible and successful experiments.

In vitro/In vivo correlation of biphasic dissolution methods that mimic oral absorption from simulated rat gastrointestinal fluids

A low volume biphasic dissolution and partition method was used to simulate the gastrointestinal (GI) fluid and luminal conditions of a fasted state rat in order to compare the partition rate of a development compound to in vivo absorption. 

A biphasic dissolution method to mimic oral absorption from simulated animal gastrointestinal fluids

A low volume biphasic dissolution method was developed to control a dynamic pH environment in the presence of simulated dog and rat GI media. Experiments were performed with itraconazole suspensions to test the viability of the method for in situ UV analysis of partition rates under biorelevant conditions. We are very happy to discuss any aspect of our research so do contact us with any questions you may have.