Sirius inForm

Powerful instrument for bio-relevant dissolution and solubility analysis of formulations and dosage forms.

Sirius inForm

Sirius inForm measures the kinetics of dissolution, absorption, controlled supersaturation and precipitation, and accommodates multiple dosage forms and sample types. It provides high quality support for formulation development and reflects industry's growing interest in dissolution to support in vivo prediction.

Dissolution: Biorelevant, biphasic, automated

Sirius inForm bridges the gap between research-based micro-scale dissolution and the compendial world. Innovative methods such as biphasic dissolution and gradient pH adjustments show how a drug would behave under biorelevant conditions. Automation and precision engineering ensure that dissolution experiments are accurate and highly reproducible.

Solubility, controlled supersaturation, precipitation

With many new drugs now requiring solubility enhancement, formulators need ways to characterize supersaturation and precipitation. Sirius inForm measures solubility using the CheqSol method; new assays report the extent and duration of supersaturation, precipitation rates and excipient gain factors. Uniquely, concentrations are calculated from measured pH, which eliminates interference by suspended solids. There is also a UV option for controlled supersaturation studies.

A versatile platform

Sirius inForm is a versatile platform for automated analysis of solutions. It provides temperature control and high quality stirring, pH measurement and control, ability to add sampleĀ  and reagents automatically, in-situ UV measurement and the ability to remove aliquots of sample for off-line analysis. Lipolysis assays to study digestion of lipid-based formulations are supported. UV enhancements include multi-component sensing, and Tyndall Rayleigh scattering correction to reduce the effect of suspended solids during dissolution studies.