This unique surface dissolution imager provides the ability to look directly at the solid-liquid interface as the sample dissolves.
Sirius SDI with ActipixTM Technology
Suface Dissolution Imaging
The Sirius SDI (Surface Dissolution Imager) provides the ability to look directly at the solid-liquid interface as a sample is dissolving. Real-time ultra-violet (UV) movies of the dissolution process can be gained microns from the drug surface. Typical experiments last 30 minutes and require 2mg of sample and 20mL of dissolution medium. The Sirius SDI includes ActiPix™ UV area imaging technology, a flow cell and sample holder, an integrated syringe pump and software. Data can be recorded and reviewed in real time. The flow cell provides a constant velocity of laminar flow. This creates steady-state conditions so that reliable images can be recorded for each moment of flow. A 2dimensional (2-D) array of pixels collects images once per second at pre-chosen wavelengths to provide absorbance data over a 2-D area. When combined with specialized software analysis tools, the data provides a unique and time-saving insight into a compound’s behaviour. Physical changes and dissolution can be visualized simultaneously. The instrument can also be used to measure intrinsic dissolution rates, which are obtained in a fraction of time it takes when using conventional dissolution systems.
Sirius SDI has applications in new drug discovery and compound formulation. With its small sample requirements, it will preserve precious test batches and can accelerate pre-formulations development, saving months in development time.
ActiPix™, the parallel array detector at the heart of SDI provides intensity measurements at every point inside the viewing area. Thousands of pixels detect photons over a large area. Individual pixels can be selected for measurement of absorbance values. Accurate measurement of location or distance relative to any origin from the dimensions of each pixel allows for dimensional analysis and distance profiling. The absorbance values for each pixel in the selected viewing area create a 2-D image, and the images collected for the duration of the experiment are used to create a movie. High-resolution 2-D movies of UV absorbance can be captured, providing a detailed view of the dissolution process at the solid–liquid interface in real-time as it happens.