Sirius SDi2

This unique surface dissolution imager enables detailed analysis of dissolution and drug release directly at the solid-solution interface

Sirius SDi2

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The Sirius SDi2 is designed specifically to accelerate your pre-formulation and formulation development. The next generation of UV imaging from Sirius, the SDi2 is used for investigating physical processes occurring at the solid-liquid interface during dissolution. As well as measuring intrinsic dissolution and release rates of drug products, the SDi2 is ideal for quantifying swelling, erosion and disintegration kinetics of a range of whole dosage forms. The SDi2 uses a powerful 4.2 megapixel ActiPixTM detector to record ultraviolet and visible light intensity data in real-time and in two dimensions. It produces high resolution videos that record dynamic processes as they happen. The SDi2 uses a fully integrated fluidics system with a choice of two different flow cells to cover a broad range of applications and sample types.

Compact Flow Cell


Compact flow cell with direction of dissolution medium flow

  • Designed around the original Nelson and Shah flow cell for dissolution under laminar flow (Nelson, K. G.; Shah, A. C., J Pharm Sci 1975, 64 (4), 610-4).
  • Small volume cell uses minimal sample amount, ideal for research or early development

Measure IDR (intrinsic dissolution rate) of API


IDR experiments using compact flow cell. 3 mg compact of theophylline in simulated gastric fluid flowing at 0.8 mL/min. Absorbance data of theophylline in solution at A) 280 nm and B) 255 nm, obtained from a single experiment.

Whole Dosage Flow Cell


Whole dosage flow cell with capsule, showing direction of dissolution medium flow

  • Designed around well-established USP apparatus 4 cell (flow-through dissolution)
  • A unique insight into mechanistic detail whilst using familiar, widely accepted dissolution apparatus

Measure rate of swelling for extended release dosage forms


Obscuration images of an extended release dosage form in a pH shift experiment from gastric to intestinal pH, using 520 nm LED at 1) t=0 and 2) t=6 hours. Width of tablet can be measured from experimental onset.

Measure erosion & drug release from whole dosage forms


UV absorbance images of 3D printed Warfarin & Eudragit tablet in 0.1 M HCl at A) t=1 and B) t=60 minutes at 255 nm. Tablet size reduces, while drug concentration in solution increases, indicated by dark blue to light blue false colour change in dissolution medium. FDM 3D printed tablets produced by Dr. Basel Arafat and Dr. Mohammed AlbedAlhnan , The School of Pharmacy and Biomedical Sciences, UCLAN, Preston, UK.