Products

Sirius SDi2

This unique surface dissolution imager enables detailed analysis of dissolution and drug release directly at the solid-solution interface

Features and Benefits

Features

Benefits

Visualisation of physical phenomena in real-time

Provides a unique insight into the mechanistic understanding of the dissolution/release process as it happens. Applications include:
IDR

  • Surface swelling
  • Disintegration/erosion rates
  • Cumulative mass loss/drug release
  • Concentration gradients
  • Diffusion properties
  • Microenvironmental pH changes (using pH sensitive dye)

Use of linear velocity flow enables steady state conditions, ensuring reproducible results.

Compact flow cell
 - Minimal sample requirements
 - Small cell volume
 - Compatible with a variety of
    sample types

For use in research and early development where compound availability is limited. With a design based around Nelson and Shah flow-through cell, intrinsic dissolution rates of poorly soluble drugs can be measured in minutes, rather than hours or days. Study powders, suspensions, creams, gels, liquids, granules, crystals, stents, implants and transdermal patches.

Whole dosage flow cell
 - Compatible with variety
    of dosage forms

For use in formulation and development of final dosage form. Design is based on USP apparatus 4 flow cell, using equivalent linear velocities with the added benefit of real-time visualisation. Study tablets, powder/gel capsules and extended release formulations.

Dual wavelength capability

A selection of narrow bandwidth LEDs provide the light source, including 4 UV wavelengths and one in the visible range. Two wavelengths can be selected, allowing the user to study drug concentration in solution and solid state effects or drug versus excipient behaviour in a single experiment.

Fully integrated and automated fluidics system
 - Use one or two media per
    experiment
 - Open or closed loop
 - Use biorelevant media Multiple
    flow rates per experiment

Highly flexible and automated fluidics system has been designed for ease of use. Default methods are provided, for example, to study the effect of pH change from gastric to intestinal media in a single experiment and using physiologically relevant flow rates. Standard fittings give users the freedom to add their own analytics inline if required.

Raman Compatible

Additional viewing window on compact cell allows for in-situ UV imaging and Raman data to be recorded in a single experiment