Sirius Scissor
In vitro testing for injection site events for biopharmaceuticals
Features and Benefits
Features |
Benefits |
A sophisticated model of the subcutaneous and intraocular spaces |
Allows accurate modelling of the in vivo behaviour of injectable biopharmaceuticals |
Excellent correlation between data obtained and human release/bioavailability from multiple, well characterised protein and antibody formulations |
System generates the same release profiles and rank orders of bioavailability as observed in humans |
Easily managed experiments |
Can be used during formulation development for excipient screening in order to assess the impact in human bioavailability |
Custom-designed extra-cellular matrix cartridge provides a very accurate simulation of the extracellular matrix. The modelled capillary transport system mimics precisely the infinite sink conditions of human bloodstream |
Accurate simulation of injected drug’s behaviour at the injection and absorption stages |
Option for automated sample collection |
Allows users to run unattended assays |
ISF buffer chamber and ECM are magnetically stirred during tests |
Stirring simulates the active environment of the human body |
4-channel light transmission through cartridge |
Rapid, effective detection of turbidity allows visualisation of events such precipitation or dissolution of particles in suspension |
pH controlled by physiologically relevant buffers with a feedback loop |
Extremely tight pH control using a biorelevant buffer ensures a perfect replication of the conditions in the human body and |
Syringe station holds cartridge injection syringe in a fixed position |
Reproducible injections enable meaningful data comparison |
Intuitive Control Software - Excel based data report |
Easy to mine data and produce reports |