PKa values influence behaviour such absorption, binding and salt selection, as well as influencing other physicochemical properties such as lipophilicity, solubility and dissolution.

For a clear and up-to-date review, view our 2012 webinar on “How pKa Values are used in the Pharmaceutical Industry” and download our Applications Notes for the Fast UV pKa method, Measurement of extreme pKas, and the use of cosolvent pKa assays for poorly soluble compounds.